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Desomorphine or dihydrodesoxymorphine is an opioid, like morphine or heroin. That means it is a powerful painkiller, but like morphine and heroin it is also highly addictive. It was originally synthesized in 1932 and patented in 1934 by American chemist Lyndon Frederick Small.

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Desomorphine or dihydrodesoxymorphine is an opioid, like morphine or heroin. That means it is a powerful painkiller, but like morphine and heroin it is also highly addictive. It was originally synthesized in 1932 and patented in 1934 by American chemist Lyndon Frederick Small. 

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Inspired by the discovery of novocaine, a safer version of cocaine which didn’t display the same addictive properties, they wanted to side-step the addictive nature of morphine. Small’s method involved modifying the functional groups of the morphine molecule in the hope of decreasing undesirable addictive effects while increasing the pain-relieving effects. His work produced many research papers, and new promising leads including the drugs metopon and monoacetylmorphine as well as desomorphine. 

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Clinical studies of desomorphine showed that the drug was eight to 10 times more potent than morphine, requiring lower doses for pain relief, muscle-relaxation, sedation and euphoria, as well as decreasing the nausea and respiratory depression associated with the use of morphine. Although these were positive outcomes from the research, use of the drug also quickly leads to addiction – in fact it showed an increased potential for dependence compared with morphine. Desomorphine was briefly commercially produced by Roche in the 1940s under the trade name Permonid and was used for post-operative pain relief due to its quick onset and decreased respiratory depression, but was found to have a short shelf life and was removed from the market in 1952. 

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That might have been it for desomorphine, as these problems left little reason to invest and market such a product. But the story doesn’t end there. In recent years, desomorphine has emerged as a substitute for heroin in Russia 

krokodil Best Price Online 

As with the highly addictive crystal methamphetamine, produced because of the readily available precursors in cold and flu medication, krokodil is an untended result of a number of factors combining. It’s an unhappy twist in the tale of a drug produced as a byproduct of research into non-addictive morphine substitutes. 

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